BMS-986251
Product Specifications
CAS Number
2460133-35-9
Target
Others, Interleukin, ROR
Related Pathways
Metabolism, Immunology/Inflammation, Others
Bioactivity
BMS-986251 is a potent and specific RORγt inverse agonist that exerts its action via oral administration. It shows an EC 50 of 12 nM for RORγt GAL4. In human whole blood assay, BMS-986251 effectively inhibits IL-17 with an EC 50 of 24 nM. Furthermore, BMS-986251 exhibits strong therapeutic effects in mouse acanthosis and Imiquimod-induced models, which are commonly used preclinical models for psoriasis.
Smiles
[H][C@@]12CCc3cc(ccc3[C@@]1(CCN2C(=O)[C@@H]1CC[C@H](C[C@@H]1C)C(O)=O)S(=O)(=O)c1ccc(F)cc1)C(F)(C(F)(F)F)C(F)(F)F
Molecular Formula
C30H29F8NO5S
Molecular Weight
667.61
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
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