SHP2-D26
Product Specifications
CAS Number
2458219-65-1
Target
Phosphatase, PROTACs
Related Pathways
Metabolism, PROTAC
Bioactivity
SHP2-D26 is a highly potent and effective SHP2 degrader. Its mechanism of action involves the induction of SHP2 degradation through binding to VHL-1 and SHP2 proteins. Additionally, the degradation of SHP2 induced by SHP2-D26 is dependent on neddylation and proteasome activity.
Smiles
C[C@H](NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)[C@@H](NC(=O)CCCCCCCCN1CCN(CC1)C(=O)CCC(=O)Nc1cccc(Sc2ncc(nc2N)N2CCC(C)(N)CC2)c1Cl)C(C)(C)C)c1ccc(cc1)-c1scnc1C |@@:61|
Molecular Formula
C56H79ClN12O6S2
Molecular Weight
1115.9
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
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