BMS-1166-N-piperidine-CO-N-piperazine
Product Specifications
CAS Number
2447066-14-8
Target
Target Protein Ligand-Linker Conjugate, Others
Related Pathways
Others, PROTAC
Bioactivity
BMS-1166-N-piperidine-CO-N-piperazine is a chemical compound containing a PD-1/PD-L1 immune checkpoint ligand and a PROTAC linker. It is used in synthesizing [PROTAC PD-1/PD-L1 degrader-1], which effectively inhibits the PD-1/PD-L1 interaction with an IC50 value of 39.2 nM.
Smiles
Cc1c(COc2cc(OCc3cccc(c3)C#N)c(CN3CCCCC3C(=O)N3CCNCC3)cc2Cl)cccc1-c1ccc2OCCOc2c1
Molecular Formula
C41H43ClN4O5
Molecular Weight
707.27
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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