PROTAC BRD4 Degrader-15
Product Specifications
CAS Number
2417370-67-1
Target
Others, PROTACs, Epigenetic Reader Domain
Related Pathways
Others, Chromatin/Epigenetic, PROTAC
Bioactivity
PROTAC BRD4 Degrader-15 is a chemical compound consisting of a PROteolysis TArgeting Chimera (PROTAC) linked to ligands specific to von Hippel-Lindau and BRD4. It exhibits an IC50 of 7.2 nM for BRD4 BD1 and 8.1 nM for BRD4 BD2 and demonstrates potent degradation activity against the BRD4 protein in PC3 prostate cancer cells.
Smiles
Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCc2cc(N)cc(OCCNC(=O)c3cc4N(Cc5c[nH]c6c5c(cn(C)c6=O)-c4cc3CS(C)(=O)=O)c3ncc(F)cc3F)c2)C(C)(C)C)cc1 |@@:75|
Molecular Formula
C57H62F2N10O10S2
Molecular Weight
1149.3
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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