CBR-470-1
Product Specifications
CAS Number
2416095-06-0
Target
PGK1, Nrf2
Related Pathways
Immunology/Inflammation, Metabolism
Purity
0.9887
Bioactivity
CBR-470-1 is a potent inhibitor of glycolytic phosphoglycerate kinase 1 (PGK1) that activates NRF2 by increasing methylglyoxal levels. CBR-470-1 is a non-covalent Nrf2 activator with neuroprotective activity that protects SH-SY5Y neuronal cells from MPP+-induced cytotoxicity by activating the Keap1-Nrf2 cascade. cytotoxicity induced by MPP+.
Smiles
S(=O)(=O)([C@@H]1[C@@H](NCC(C)C)CS(=O)(=O)C1)C2=CC=C(Cl)C=C2
Molecular Formula
C14H20ClNO4S2
Molecular Weight
365.9
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
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