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(±) -Equol

Product Specifications

CAS Number

94105-90-5

Target

Estrogen Receptor/ERR, Estrogen/progestogen Receptor, Drug Metabolite

Related Pathways

Metabolism, Endocrinology/Hormones

Purity

0.9849

Bioactivity

(±) -Equol ((R, S) -Equol) is a non-steroidal estrogen produced from the metabolism of the isoflavonoid phytoestrogen daidzen by human intestinal microflora. The estrogen receptor (ER) agonist activity of the naturally occurring (S) -enantiomer (EC50 = 85 and 65 nM for human ERα and ERβ, respectively) is similar to that of genistein but exceeds that of daidzein. (±) -Equol preferentially binds ERβ (Ki = 0.73 nM) and demonstrates approximately 9-fold lower affinity for ERα (Ki = 6.41 nM) . (±) -Equol is also a potent antagonist of dihydrotestosterone, which has important implications for prostate cancer and other androgen-mediated pathologies.

Smiles

OC=1C=C2C(CC(CO2)C3=CC=C(O)C=C3)=CC1

Molecular Formula

C15H14O3

Molecular Weight

242.27

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

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