AP14145 hydrochloride
Product Specifications
CAS Number
2387505-59-9
Target
Others|||Potassium Channel
Related Pathways
Others|||Membrane transporter/Ion channel
Bioactivity
AP14145 hydrochloride is a potent negative allosteric modulator of K Ca 2 (SK) channels, specifically targeting K Ca 2.2 (SK2) and K Ca 2.3 (SK3) channels with an IC 50 of 1.1 ?M. Inhibition of AP14145 hydrochloride is highly influenced by S508 and A533 amino acids present in the channel. This compound effectively extends the atrial effective refractory period (AERP) in rats and exhibits antiarrhythmic properties in a Vernakalant-resistant porcine model of atrial fibrillation (AF) .
Smiles
Cl.C[C@@H](Nc1nc2cccc(NC(C)=O)c2[nH]1)c1cccc(c1)C(F)(F)F
Molecular Formula
C18H18ClF3N4O
Molecular Weight
398.81
Shipping Conditions
Cool pack
Storage Temperature
-20°C
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