(32-Carbonyl) -RMC-5552
Product Specifications
CAS Number
2382768-55-8
Target
MTOR|||Others
Related Pathways
PI3K/Akt/mTOR signaling|||Others
Bioactivity
(32-Carbonyl) -RMC-5552 is a highly effective mTOR inhibitor, inhibiting both mTORC1 and mTORC2 substrate phosphorylation. It significantly suppresses the phosphorylation of p-P70S6K- (T389), p-4E-BP1- (T37/36), and p-AKT1/2/3- (S473) with pIC50 values >9, >9, and 8~9, respectively.
Smiles
[H][C@@]12CC[C@@H](C)[C@@](O)(O1)C(=O)C(=O)N1CCCC[C@@]1([H])C(=O)O[C@@]([H])(CC(=O)[C@H](C)\C=C(C)\[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)\C=C\C=C\C=C(C)\[C@H](C2)OC)[C@H](C)C[C@@H]1CC[C@@H](OC(=O)NCCOCCOCCOCCOCCOCCOCCOCCOCCC(=O)N2CCc3cc(Cn4nc(-c5ccc6oc(N)nc6c5)c5c(N)ncnc45)ccc3C2)[C@@H](C1)OC
Molecular Formula
C93H134N10O24
Molecular Weight
1776.141
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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