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CDK4/6-IN-5

Product Specifications

CAS Number

2380321-50-4

Target

Others, CDK

Related Pathways

Cell Cycle/Checkpoint, Others

Bioactivity

CDK4/6-IN-5 is a highly effective inhibitor of CDK4 and CDK6, with Ki values of 0.2 nM for CDK4/Cyclin D1 and 4.4 nM for CDK6/Cyclin D3 (WO2019207463A1, example A93) .

Smiles

C[C@@H](O)c1nc2c(F)cc(cc2n1C(C)C)-c1nc(N[C@@H]2CCN(C[C@H]2O)S(C)(=O)=O)ncc1Cl

Molecular Formula

C22H28ClFN6O4S

Molecular Weight

527.01

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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