MS98
Product Specifications
Target
Others|||PROTACs|||Akt
Related Pathways
Cytoskeletal Signaling|||PROTAC|||PI3K/Akt/mTOR signaling|||Others
Bioactivity
MS98 is a highly effective and specific PROTAC AKT degrader compound that effectively targets and depletes total AKT (T-AKT) within cells, exhibiting a DC 50 value of 78 nM. This compound readily binds to AKT1, AKT2, and AKT3 with respective dissociation constants (Kd s) of 4 nM, 140 nM, and 8.1 nM.
Smiles
C[C@H](NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)[C@@H](NC(=O)CCCCCCCCCCC(=O)NCCNC[C@@H](C(=O)N1CCN(CC1)c1ncnc2[C@H](O)C[C@@H](C)c12)c1ccc(Cl)cc1)C(C)(C)C)c1ccc(cc1)-c1scnc1C
Molecular Formula
C58H81ClN10O7S
Molecular Weight
1097.86
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Product Datasheet
https://www.targetmol.com/attachment/DataSheet/5DF6A1E0-BF78-49A1-B9CC-D313643706FA/T39930
CAS Number
2376137-31-2
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