MS170
Product Specifications
CAS Number
2376136-61-5
Target
PROTACs|||Akt
Related Pathways
PROTAC|||PI3K/Akt/mTOR signaling|||Cytoskeletal Signaling
Bioactivity
MS170 is a highly effective and specific PROTAC AKT degrader compound that exhibits potent activity. It efficiently reduces the levels of total AKT (T-AKT) within cells, with a DC 50 value of 32 nM. Furthermore, MS170 demonstrates strong binding affinity towards AKT isoforms, specifically AKT1, AKT2, and AKT3, with respective dissociation constants (Kd) of 1.3 nM, 77 nM, and 6.5 nM.This compound is unstable in powder form and other related salt forms are recommended.
Smiles
C[C@@H]1C[C@@H](O)c2ncnc(N3CCN(CC3)C(=O)[C@H](CNCCC(=O)NCCCCCCCCNc3cccc4C(=O)N(C5CCC(=O)NC5=O)C(=O)c34)c3ccc(Cl)cc3)c12
Molecular Formula
C45H56ClN9O7
Molecular Weight
870.45
Shipping Conditions
Cool pack
Storage Temperature
-20°C
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