Zeteletinib hemiadipate
Product Specifications
CAS Number
2375837-06-0
Target
C-RET|||Others|||PDGFR
Related Pathways
Angiogenesis|||Tyrosine Kinase/Adaptors|||Apoptosis|||Others
Bioactivity
Zeteletinib hemiadipate (BOS-172738; DS-5010) is an orally active compound that functions as a selective inhibitor of RET kinase. It exhibits nanomolar potency against RET and a 300-fold selectivity towards VEGFR2. Notably, Zeteletinib hemiadipate demonstrates exceptional effectiveness against various forms of RET, including the wild type, RET V804M/L gatekeeper mutants, and the oncogenic RET mutation M918T. Additionally, Zeteletinib hemiadipate exerts potent antitumor effects.
Smiles
OC(=O)CCCCC(O)=O.COc1cc2cc(cnc2cc1OC)-c1ccc(CC(=O)Nc2cc(no2)C(C)(C)C(F)(F)F)cn1.COc1cc2cc(cnc2cc1OC)-c1ccc(CC(=O)Nc2cc(no2)C(C)(C)C(F)(F)F)cn1
Molecular Formula
C56H56F6N8O12
Molecular Weight
1147.098
Shipping Conditions
Cool pack
Storage Temperature
-20°C
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