GNE-274
Product Specifications
CAS Number
2369048-69-9
Target
Others, Estrogen Receptor/ERR
Related Pathways
Others, Endocrinology/Hormones
Bioactivity
GNE-274, a non-degrader compound structurally similar to GDC-0927 (an ER degrader), serves as a partial ER agonist in breast cancer cell lines without triggering ER turnover. Notably, GNE-274 enhances chromatin accessibility at ER-DNA binding sites, unlike GDC-0927. Acting as a potent inhibitor of the ER-ligand binding domain (LBD), GNE-274 exhibits potential for cancer research purposes.
Smiles
CCCN1CC(COc2ccc(cc2)[C@@H]2Oc3ccc(O)cc3C(C)=C2c2cccc(O)c2)C1
Molecular Formula
C29H31NO4
Molecular Weight
457.57
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
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