Desmorpholinyl Navitoclax-NH-Me
Product Specifications
CAS Number
2365172-82-1
Target
Bcl-2 Family, Ligands for Target Protein for PROTAC
Related Pathways
Apoptosis, PROTAC
Purity
0.9987
Bioactivity
Desmorpholinyl Navitoclax-NH-Me (Desmorpholinyl ABT-263-NH-Me) is a Bcl-xL inhibitor, which can be employed alongside a CRBN ligand to synthesize XZ739, a PROTAC BCL-XL degrader [1] [2].
Smiles
CNCC[C@H](CSc1ccccc1)Nc1ccc(cc1S(=O)(=O)C(F)(F)F)S(=O)(=O)NC(=O)c1ccc(cc1)N1CCN(CC2=C(CCC(C)(C)C2)c2ccc(Cl)cc2)CC1
Molecular Formula
C44H51ClF3N5O5S3
Molecular Weight
918.55
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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