ARD-61
Product Specifications
CAS Number
2316837-08-6
Target
PROTACs, Androgen Receptor, Apoptosis, Progesterone Receptor
Related Pathways
Endocrinology/Hormones, Others, Apoptosis, PROTAC
Bioactivity
ARD-61 is a potent and specific PROTAC androgen receptor (AR) degrader, exhibiting high effectiveness. It effectively induces the degradation of AR and progesterone receptors (PR) in AR+ cancer cell lines, leading to apoptosis. Additionally, ARD-61 demonstrates significant tumor growth inhibition in the MDA-MB-453 xenograft model in mice.
Smiles
CC(C)[C@@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)N[C@@H](CC(=O)N1CCC(CC1)N1CCC(CC1)C#Cc1ccc(cc1)C(=O)N[C@H]1C(C)(C)[C@H](Oc2ccc(C#N)c(Cl)c2)C1(C)C)c1ccc(cc1)-c1scnc1C)c1cc(C)no1
Molecular Formula
C61H71ClN8O7S
Molecular Weight
1095.8
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
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