Desmorpholinyl Quizartinib-PEG2-COOH
Product Specifications
CAS Number
2292116-14-2
Target
Others|||Target Protein Ligand-Linker Conjugate
Related Pathways
Others|||PROTAC
Bioactivity
Desmorpholinyl Quizartinib-PEG2-COOH is a compound featuring an FLT-3 ligand and a PEG-based PROTAC linker. It is employed in the synthesis of PROTAC FLT-3 degrader 1, which serves as a degrader for the FLT-3 internal tandem duplication (ITD) through PROTAC technology. The degrader exhibits an IC50 of 0.6 nM.
Smiles
CC(C)(C)c1cc(NC(=O)Nc2ccc(cc2)-c2cn3c(n2)sc2cc(OCCOCCOCCC(O)=O)ccc32)no1
Molecular Formula
C30H33N5O7S
Molecular Weight
607.68
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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