Su1498
Product Specifications
CAS Number
168835-82-3
Target
VEGFR
Related Pathways
Tyrosine Kinase/Adaptors, Angiogenesis
Purity
>99.99%
Bioactivity
Su1498 (Tyrphostin SU 1498) is a selective inhibitor of the receptor tyrosine kinase VEGF receptor 2 (VEGFR2, aka FLK1; IC50 = 700 nM), having negligible activity at several other serine/threonine and tyrosine kinases.1, 2 It effectively blocks signaling through VEGFR2 both in vitro and in vivo.1, 3 SU 1498 is used to study the role of VEGFR2 signaling in diverse processes, including angiogenesis, tumor growth, neural progenitor cell survival, and neuroregeneration.
Smiles
CC(C)c1cc(\C=C(/C#N)C(=O)NCCCc2ccccc2)cc(C(C)C)c1O
Molecular Formula
C25H30N2O2
Molecular Weight
390.52
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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