LpxC-IN-5
Product Specifications
CAS Number
2253951-38-9
Target
Others, Antibacterial
Related Pathways
Others, Microbiology/Virology
Bioactivity
LpxC-IN-5 is a potent, non-hydroxamate inhibitor of LpxC, which is an enzyme known as UDP-3-O-acyl-N-acetylglucosamine deacetylase. It exhibits an IC50 value of 20 nM. Furthermore, LpxC-IN-5 displays antibacterial activity against various strains including E. coli ATCC25922, P. aeruginosa ATCC27853, K. pneumoniae ATCC13883, and P. aeruginosa 5567. The minimum inhibitory concentration (MIC) values for these strains are 16 μg/mL, 4 μg/mL, 64 μg/mL, and 4 μg/mL, respectively.
Smiles
C[C@H](O)c1nccn1Cc1cc(on1)C#Cc1ccc(OCC(N)(CO)CO)cc1
Molecular Formula
C21H24N4O5
Molecular Weight
412.446
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
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