KRH-3955 hydrochloride
Product Specifications
CAS Number
2253744-59-9
Target
Others|||CXCR|||HIV Protease
Related Pathways
Microbiology/Virology|||Others|||Immunology/Inflammation|||Proteases/Proteasome|||Autophagy|||GPCR/G Protein
Bioactivity
KRH-3955 hydrochloride is a CXCR4 antagonist with oral bioavailability. It effectively inhibits the binding of SDF-1? to CXCR4, exhibiting an IC 50 of 0.61 nM. Additionally, KRH-3955 hydrochloride displays high potency and selectivity as an inhibitor of X4 HIV-1, with an EC 50 ranging from 0.3 to 1.0 nM.
Smiles
Cl.Cl.Cl.CCCN(CCC)CCCCN(C)Cc1ccc(CN(Cc2ncc[nH]2)Cc2nccn2C)cc1
Molecular Formula
C28H48Cl3N7
Molecular Weight
589.09
Shipping Conditions
Cool pack
Storage Temperature
-20°C
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