DBCO-PEG4-Val-Cit-PAB-MMAF

Product Specifications

CAS Number

2244602-23-9

Target

Drug-Linker Conjugates for ADC

Related Pathways

Antibody-drug Conjugate/ADC Related

Bioactivity

DBCO-PEG4-Val-Cit-PAB-MMAF is a chemical compound consisting of a cleavable 4 unit polyethylene glycol antibody-drug conjugate (ADC) linker (DBCO-PEG4-Val-Cit-PAB) and a potent inhibitor of tubulin polymerization (MMAF) . This compound is an essential component in the synthesis of ADCs.

Smiles

[H][C@]([C@@H](C)CC)([C@@H](CC(=O)N1CCC[C@@]1([H])[C@H](OC)[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(O)=O)OC)N(C)C(=O)[C@@H](NC(=O)[C@H](C(C)C)N(C)C(=O)OCc1ccc(NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@@H](NC(=O)CCOCCOCCOCCOCCNC(=O)CCC(=O)N2Cc3ccccc3C#Cc3ccccc23)C(C)C)cc1)C(C)C