ASP2453
Product Specifications
CAS Number
2241719-73-1
Target
Ras, ERK, Kras
Related Pathways
MAPK, GPCR/G Protein
Purity
0.9971
Bioactivity
ASP2453 is a potent, selective, and covalent inhibitor of KRAS G12C that inhibits the Son of Sevenless (SOS) -mediated interaction between KRAS G12C and Raf with an IC50 value of 40 nM.
Smiles
COCCCN1CCC(CC1)Oc1nc(N2CCC3(CN(C3)C(=O)C=C)CC2)c2cc(C3CC3)c(c(OCC(F)(F)F)c2n1)-c1c(C)ccc2[nH]ncc12
Molecular Formula
C40H48F3N7O4
Molecular Weight
747.85
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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