Crelosidenib
Product Specifications
CAS Number
2230263-60-0
Target
Isocitrate Dehydrogenase (IDH), Dehydrogenase
Related Pathways
Metabolism
Purity
0.9854
Bioactivity
Crelosidenib is a potent and selective mutant IDH inhibitor with IC50s of 6.27 nM, 3.71 nM, 36.9 nM, and 11.5 nM for IDH1 R132H, IDH1 R132C, IDH2 R140Q, and IDH2 R172K mutases, respectively, and low inhibitory activity against the wild-type IDH enzyme.
Smiles
[C@H](CC1CC1)(C2=CC=C([C@@H](NC=3N=C4C(=CN3)COC(=O)N4CC)C)C=C2)N5CCN(C(C=C)=O)CC5
Molecular Formula
C28H36N6O3
Molecular Weight
504.62
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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