ARV-471
Product Specifications
CAS Number
2229711-68-4
Target
Estrogen Receptor/ERR, PROTACs
Related Pathways
Endocrinology/Hormones, PROTAC
Purity
>99.99%
Bioactivity
Vepdegestrant (ARV-471) is an estrogen receptor (ER) α PROTAC molecule that degrades ER in ER-positive breast cancer cell lines with a DC50 of approximately 1 nM. It can reduce the expression of classically regulated ER target genes and inhibit the growth of ER-dependent cell lines (including those expressing ESR1 variants, such as Y537S and D538G) by degrading ER.
Smiles
OC=1C=C2C([C@H]([C@H](CC2)C3=CC=CC=C3)C4=CC=C(C=C4)N5CCC(CN6CCN(CC6)C=7C=C8C(=CC7)C(=O)N(C8)[C@@H]9C(=O)NC(=O)CC9)CC5)=CC1
Molecular Formula
C45H49N5O4
Molecular Weight
723.9
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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