Multitarget AD inhibitor-1
Product Specifications
CAS Number
2205015-77-4
Target
Others, Cholinesterase (ChE), Beta-Secretase, Beta Amyloid
Related Pathways
Neuroscience, Others
Bioactivity
Multitarget AD inhibitor-1 is a reversible and selective inhibitor of butyrylcholinesterase (BuChE) with IC50 values of 7.22 μM for human BuChE (hBuChE) and 1.55 μM for equine serum BuChE (eqBuChE) . It also exhibits inhibitory activity towards β-secretase (IC50 41.60 μM), amyloid β aggregation (IC50 3.09 μM), and tau aggregation. As a diphenylpropylamine derivative, Multitarget AD inhibitor-1 is promising for research into multifunctional, disease-modifying treatments for Alzheimer's disease.
Smiles
CC(C)(C)c1cccc(CNCC(O)CNCCC(c2ccccc2)c2ccccc2)c1
Molecular Formula
C29H38N2O
Molecular Weight
430.636
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
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