(R) -GSK-3685032
Product Specifications
CAS Number
2170140-50-6
Target
Others, DNA Methyltransferase
Related Pathways
Chromatin/Epigenetic, Others
Bioactivity
(R) -GSK-3685032 is the R-enantiomer of GSK-3685032, a first-in-class, non-time-dependent, non-covalent, reversible, selective DNMT1 inhibitor with an IC50 of 0.036 μM, which induces robust loss of DNA methylation, transcriptional activation, and inhibition of cancer cell growth.
Smiles
CCc1c(C#N)c(S[C@@H](C(N)=O)c2ccccc2)nc(N2CCC(N)CC2)c1C#N
Molecular Formula
C22H24N6OS
Molecular Weight
420.54
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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