APJ receptor agonist 4
Product Specifications
CAS Number
2135515-67-0
Target
Apelin receptor, Others
Related Pathways
GPCR/G Protein, Others
Bioactivity
APJ Receptor Agonist 4 is a potent, orally active apelin receptor (APJ) agonist, demonstrating an EC50 of 0.06 nM and a Ki of 0.07 nM. It exhibits excellent pharmacokinetic profiles in rodent heart failure (HF) models and has shown an acceptable safety profile in preclinical toxicology studies. This compound effectively improves cardiac function, making it valuable for research into HF disease.
Smiles
CCc1cccc(CC)c1-n1c(O)c(C(=O)N2CCC(C2)c2ncc(Cl)cc2F)c(=O)nc1-c1ccn(C)n1
Molecular Formula
C28H28ClFN6O3
Molecular Weight
551.02
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
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