TAK-960 monohydrochloride
Product Specifications
CAS Number
2108449-45-0
Target
Others, PLK
Related Pathways
Cell Cycle/Checkpoint, Others
Bioactivity
TAK-960 monohydrochloride is an orally available compound that selectively inhibits polo-like kinase 1 (PLK1) with an IC50 of 0.8 nM. It also demonstrates inhibitory activity against PLK2 (IC50 of 16.9 nM) and PLK3 (IC50 of 50.2 nM), and effectively suppresses the proliferation of various cancer cell lines, exhibiting significant efficacy against multiple tumor xenografts.
Smiles
Cl.COc1cc(C(=O)NC2CCN(C)CC2)c(F)cc1Nc1ncc2N(C)C(=O)C(F)(F)CN(C3CCCC3)c2n1
Molecular Formula
C27H35ClF3N7O3
Molecular Weight
598.07
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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