TAK-960 monohydrochloride

TAK-960 monohydrochloride is an orally available compound that selectively inhibits polo-like kinase 1 (PLK1) with an IC50 of 0.8 nM. It also demonstrates inhibitory activity against PLK2 (IC50 of 16.9 nM) and PLK3 (IC50 of 50.2 nM), and effectively suppresses the proliferation of various cancer cell lines, exhibiting significant efficacy against multiple tumor xenografts.