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PI3K?-IN-8

Product Specifications

CAS Number

2101518-75-4

Target

PI3K|||Others

Related Pathways

Others|||PI3K/Akt/mTOR signaling

Bioactivity

PI3K?-IN-8 is a powerful and specific oral inhibitor of PI3K?, exhibiting an IC50 of 3.3 nM. It demonstrates preferential inhibition of PI3K? when compared to PI3K?, PI3K?, and PI3K?, with IC50 values of 377.2 nM, 241.6 nM, and 17.9 nM, respectively. Furthermore, PI3K?-IN-8 possesses notable anti-tumor efficacy.

Smiles

C[C@H](Nc1nc(N)nc(N)c1C#N)c1c(-c2ccc(F)cc2)c2ccc(F)cn2c(=O)c1-c1ccccc1

Molecular Formula

C28H21F2N7O

Molecular Weight

509.521

Shipping Conditions

Cool pack

Storage Temperature

-20°C

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