PI3Kδ-IN-8
Product Specifications
CAS Number
2101518-75-4
Target
PI3K, Others
Related Pathways
Others, PI3K/Akt/mTOR signaling
Bioactivity
PI3Kδ-IN-8 is a powerful and specific oral inhibitor of PI3Kδ, exhibiting an IC50 of 3.3 nM. It demonstrates preferential inhibition of PI3Kδ when compared to PI3Kα, PI3Kβ, and PI3Kγ, with IC50 values of 377.2 nM, 241.6 nM, and 17.9 nM, respectively. Furthermore, PI3Kδ-IN-8 possesses notable anti-tumor efficacy.
Smiles
C[C@H](Nc1nc(N)nc(N)c1C#N)c1c(-c2ccc(F)cc2)c2ccc(F)cn2c(=O)c1-c1ccccc1
Molecular Formula
C28H21F2N7O
Molecular Weight
509.521
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
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