DL-TBOA ammonium
Product Specifications
CAS Number
2093503-71-8
Target
Others, transporter
Related Pathways
Metabolism, Others
Bioactivity
DL-TBOA ammonium is a potent, non-transportable inhibitor of excitatory amino acid transporters. Its inhibitory effects are demonstrated by IC50 values of 70 μM, 6 μM, and 6 μM for excitatory amino acid transporter-1 (EAAT1), EAAT2, and EAAT3, respectively. Additionally, DL-TBOA ammonium significantly hampers the uptake of [14C]glutamate in COS-1 cell lines expressing human EAAT1 and EAAT2, evident by Ki values of 42 μM and 5.7 μM, respectively. Furthermore, this compound competitively blocks EAAT4 and EAAT5, with Ki values of 4.4 μM and 3.2 μM, respectively.
Smiles
N.N[C@@H]([C@H](OCc1ccccc1)C(O)=O)C(O)=O
Molecular Formula
C11H16N2O5
Molecular Weight
256.258
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
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