Aclimostat
Product Specifications
CAS Number
2082752-83-6
Target
Others|||Aminopeptidase
Related Pathways
Metabolism|||Others
Bioactivity
Aclimostat (ZGN-1061) is a highly potent inhibitor of the MetAP2 enzyme, demonstrating promising efficacy and safety profiles in preclinical trials. In a mouse model of obesity and insulin resistance, ZGN-1061 shows comparable weight loss efficacy to beloranib and improves metabolic parameters. Additionally, ZGN-1061 induces consistent changes in gene transcription in HepG2 cells, further supporting its positive pharmacological effects.
Smiles
[H][C@@]1([C@H](OC)[C@@H](CC[C@]11CO1)OC(=O)N1CC(CCN2CCOCC2)C1)[C@@]1(C)O[C@@H]1CC=C(C)C
Molecular Formula
C26H42N2O6
Molecular Weight
478.63
Shipping Conditions
Cool pack
Storage Temperature
-20°C
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