Suomilide

Suomilide effectively inhibits human trypsin-2 and trypsin-3, displaying IC50 values of 4.7 nM and 11.5 nM, respectively. Additionally, it exhibits inhibition of trypsin-1 with an IC50 value of 104 nM.

[H][C@@]12NC(=O)O[C@@]11C[C@@H](C[C@]([H])([C@@H]1O)N([C@H]2C(=O)NCCC1=CCN(C1)C(N)=N)C(=O)[C@H](NC(=O)[C@H](COS(O)(=O)=O)OC)[C@@H](C)CC)O[C@H]1O[C@H](COC(=O)CCCCC)[C@@H](O)[C@H](O)[C@H]1OC(=O)CCCCC |t:24,TLB:48:8:12:1.15.14|