MW-150 hydrochloride
Product Specifications
CAS Number
1923773-01-6
Target
Autophagy, p38 MAPK, Others
Related Pathways
Others, Autophagy, MAPK
Bioactivity
MW-150 hydrochloride (MW01-18-150SRM hydrochloride) is a potent and selective inhibitor of p38α MAPK with a Ki value of 101 nM. It exhibits excellent CNS penetration and oral bioavailability, and effectively suppresses the phosphorylation of MK2, a substrate of endogenous p38α MAPK, in activated glial cells.
Smiles
Cl.CN1CCN(CC1)c1cc(-c2ccncc2)c(nn1)-c1ccc2ccccc2c1
Molecular Formula
C24H24ClN5
Molecular Weight
417.93
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
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