CC-99677
Product Specifications
CAS Number
1887069-10-4
Target
HSP, MAPK
Related Pathways
Metabolism, MAPK, Cytoskeletal Signaling
Purity
0.9987
Bioactivity
CC-99677 (Gamcemetinib) is a selectively targeted covalent MAPKAPK2 (MK2) inhibitor for autoimmune diseases that translates biochemical potency into cellular potency as demonstrated by potent inhibition of heat shock protein 27 (HSP1) phosphorylation in LPS-activated monocyte THP-27 cells via a nucleophilic aromatic substitution (SNAr) mechanism.CC-99677 in Rat experiments demonstrated potency in both biochemical (IC 50 =156.3 nM) and cellular assays (EC 50 =89 nM) .
Smiles
CCOCc1cnc(Cl)nc1Oc1ccc2c3c4NC[C@@H](C)NC(=O)c4sc3ccc2n1
Molecular Formula
C22H20ClN5O3S
Molecular Weight
469.94
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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