CC-99677
Product Specifications
CAS Number
1887069-10-4
Target
HSP|||MAPK
Related Pathways
Metabolism|||MAPK|||Cytoskeletal Signaling
Purity
0.9987
Bioactivity
CC-99677 (Gamcemetinib) is a selectively targeted covalent MAPKAPK2 (MK2) inhibitor for autoimmune diseases that translates biochemical potency into cellular potency as demonstrated by potent inhibition of heat shock protein 27 (HSP1) phosphorylation in LPS-activated monocyte THP-27 cells via a nucleophilic aromatic substitution (SNAr) mechanism.CC-99677 in Rat experiments demonstrated potency in both biochemical (IC 50 =156.3 nM) and cellular assays (EC 50 =89 nM) .
Smiles
CCOCc1cnc(Cl)nc1Oc1ccc2c3c4NC[C@@H](C)NC(=O)c4sc3ccc2n1
Molecular Formula
C22H20ClN5O3S
Molecular Weight
469.94
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
MBS9015259 Inquire
Rabbit anti-Arabidopsis thaliana (Mouse-ear cress) PEX7 Polyclonal Antibody
Ask
View Details 
EKU08225 96 Tests
Mouse WNT1 Inducible Signaling Pathway Protein 1 (WISP1) ELISA Kit
Ask
View Details 
