Telaglenastat hydrochloride
Product Specifications
CAS Number
1874231-60-3
Target
Others, Autophagy, Glutaminase
Related Pathways
Proteases/Proteasome, Others, Autophagy
Bioactivity
Telaglenastat (CB-839) hydrochloride is a first-in-class, reversible, and orally active inhibitor of glutaminase 1 (GLS1), selectively inhibiting the splice variants KGA (kidney-type glutaminase) and GAC (glutaminase C), as opposed to GLS2. Telaglenastat hydrochloride has an IC50 of 23 nM for endogenous glutaminase in mouse kidney and 28 nM in the brain, inducing autophagy and exhibiting antitumor activity.
Smiles
Cl.FC(F)(F)Oc1cccc(CC(=O)Nc2ccc(CCCCc3nnc(NC(=O)Cc4ccccn4)s3)nn2)c1
Molecular Formula
C26H25ClF3N7O3S
Molecular Weight
608.04
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
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