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MLK-IN-1

Product Specifications

CAS Number

1627729-62-7

Target

MLK

Related Pathways

MAPK

Purity

0.9974

Bioactivity

MLK-IN-1 is a potent and selective mixed-lineage kinase 3 (MLK-3) inhibitor, showing excellent brain penetration and high specificity for MLK-3. MLK-IN-1 at 100 nM supports sustained axonogenesis in cultures challenged with HIV-1 Tat-activated microglia and protects neuronal cells from Tat-induced damage, establishing it as a valuable probe for neuroinflammation and neurodegeneration research.

Smiles

N=1C=C(C=2SC=3C(OC)=CC=CC3C2)N4N=C(C=CC14)NC5=CC=C(OC)C(OC)=C5

Molecular Formula

C23H20N4O3S

Molecular Weight

432.5

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

Frequently Asked Questions

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