MLK-IN-1
Product Specifications
CAS Number
1627729-62-7
Target
MLK
Related Pathways
MAPK
Purity
0.9974
Bioactivity
MLK-IN-1 is a potent and selective mixed-lineage kinase 3 (MLK-3) inhibitor, showing excellent brain penetration and high specificity for MLK-3. MLK-IN-1 at 100 nM supports sustained axonogenesis in cultures challenged with HIV-1 Tat-activated microglia and protects neuronal cells from Tat-induced damage, establishing it as a valuable probe for neuroinflammation and neurodegeneration research.
Smiles
N=1C=C(C=2SC=3C(OC)=CC=CC3C2)N4N=C(C=CC14)NC5=CC=C(OC)C(OC)=C5
Molecular Formula
C23H20N4O3S
Molecular Weight
432.5
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
