Uzansertib
Product Specifications
CAS Number
1620012-39-6
Target
Pim, Others
Related Pathways
Chromatin/Epigenetic, Others, JAK/STAT signaling
Bioactivity
Uzansertib (INCB053914) is a potent ATP-competitive pan-PIM kinase inhibitor. It exhibits exceptional inhibitory activity against PIM1, PIM2, and PIM3 with IC50 values of 0.24 nM, 30 nM, and 0.12 nM, respectively. Furthermore, Uzansertib demonstrates significant anti-proliferative effects against an assorted range of hematologic tumor cell lines.
Smiles
C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1c2CC[C@@H](O)c2ncc1NC(=O)c1ccc(F)c(n1)-c1c(F)cccc1F
Molecular Formula
C26H26F3N5O3
Molecular Weight
513.51
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
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