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Flavonol

Flavonol is a cholinesterase (ChE) inhibitor, with an IC50 value of 120 μM and a Ki value of 74 μM. Flavonol has antioxidant, free radical-scavenging, antibacterial properties, and immune modulation functions. Flavonol inhibits the PriA helicase of Staphylococcus aureus. Flavonol can suppress the production of NO in LPS-activated RAW 264.7 cells by inhibiting the expression of the iNOS enzyme. Flavonol shows protective and analgesic effects in mice through various neuronal pathways. Flavonol can be used in research related to tumors and atherosclerosis diseases[1][2][3][4].

Product Specifications

CAS Number

577-85-5

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Bacterial; Cholinesterase (ChE) ; Endogenous Metabolite

Type

Natural Products

Related Pathways

Anti-infection; Metabolic Enzyme/Protease; Neuronal Signaling

Field of Research

Cancer; Metabolic Disease; Inflammation/Immunology; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/flavonol.html

Concentration

10mM

Purity

99.92

Solubility

DMSO : 33.33 mg/mL (ultrasonic)

Smiles

O=C1C(O)=C(C2=CC=CC=C2)OC3=CC=CC=C13

Molecular Formula

C15H10O3

Molecular Weight

238.24

Precautions

H315, H319, H335

References & Citations

[1] Huang YH, et al. Inhibition of Staphylococcus aureus PriA Helicase by Flavonol Kaempferol. Protein J. 2015 Jun;34 (3) :169-72. |[2]Guo AJ, et al. Galangin, a flavonol derived from Rhizoma Alpiniae Officinarum, inhibits acetylcholinesterase activity in vitro. Chem Biol Interact. 2010 Sep 6;187 (1-3) :246-8. |[3]Kim HK, et al. Effects of naturally occurring flavonoids on nitric oxide production in the macrophage cell line RAW 264.7 and their structure-activity relationships. Biochem Pharmacol. 1999 Sep 1;58 (5) :759-65. |[4]Sayeli V, et al. Antinociceptive effect of flavonol and a few structurally related dimethoxy flavonols in mice. Inflammopharmacology. 2019 Dec;27 (6) :1155-1167. |[5]Phie J, et al. Flavonols reduce aortic atherosclerosis lesion area in apolipoprotein E deficient mice: A systematic review and meta-analysis. PLoS One. 2017 Jul 25;12 (7) :e0181832.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, protect from light)

Scientific Category

Natural Products

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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