Polyphyllin I

Product Specifications

CAS Number

50773-41-6

Target

Akt|||Apoptosis|||mTOR|||Autophagy|||JNK|||PDK

Related Pathways

PI3K/Akt/mTOR signaling|||Autophagy|||Cytoskeletal Signaling|||MAPK|||Apoptosis

Purity

0.995

Bioactivity

Polyphyllin D induces apoptosis via the mitochondrial apoptotic pathway as evidenced by decreased Bcl-2 expression levels, disruption of MMP and increased Bax, cytochrome C, and cleaved-caspase-3 levels. Polyphyllin D has an anti-angiogenic effect. Polyphyllin D has toxicity in human RBCs as well as its underlying mechanism for the hemolysis and eryptosis/erythroptosis. Polyphyllin D has strong anticancer activity, can overcome drug resistance in R-HepG2 cells and elicit programmed cell death via mitochondrial dysfunction.

Smiles

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