Nav1.7-IN-8
Product Specifications
CAS Number
1432913-44-4
Target
Others, Sodium Channel, Cytochromes P450
Related Pathways
Membrane transporter/Ion channel, Metabolism, Others
Bioactivity
Nav1.7-IN-8 is a highly potent and selective inhibitor of NaV1.7, exhibiting greater selectivity for inhibiting NaV1.7 compared to the subtypes hNaV1.1 and hNaV1.5. Additionally, Nav1.7-IN-8 has inhibitory effects on CYP2C9 and CYP3A4, with IC50 values of 0.17 μM and 0.077 μM, respectively. Notably, Nav1.7-IN-8 demonstrates significant analgesic properties in rodent models of both acute and inflammatory pain.
Smiles
Nc1noc2ccc(cc12)-c1cc(Cl)ccc1Oc1cc(F)c(cc1F)S(=O)(=O)Nc1ncns1
Molecular Formula
C21H12ClF2N5O4S2
Molecular Weight
535.93
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
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