Thailanstatin A
Product Specifications
CAS Number
1426953-21-0
Target
ADC Cytotoxin
Related Pathways
Antibody-drug Conjugate/ADC Related
Purity
0.9935
Bioactivity
Thailanstatin A is an ultra-potent inhibitor of eukaryotic RNA splicing (IC50 = 650 nM) . It inhibits multiple cancer cell lines via non-covalent binding to the SF3b subunit of the U2 snRNA subcomplex of the spliceosome, displaying low-nM to sub-nM IC50s. Thailanstatin A, as a payload for ADCs, is conjugated to the lysines on trastuzumab, yielding linker-less ADC.
Smiles
C[C@H](OC(C)=O)\C=C/C(=O)N[C@@H]1C[C@H](C)[C@H](C\C=C(/C)\C=C\[C@H]2O[C@H](CC(O)=O)C[C@@]3(CO3)[C@@H]2O)O[C@@H]1C
Molecular Formula
C28H41NO9
Molecular Weight
535.63
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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