Sulfo-DGN462 sodium

Product Specifications

CAS Number

1401203-09-5

Target

DNA Alkylator/Crosslinker|||ADC Cytotoxin

Related Pathways

DNA Damage/DNA Repair|||Antibody-drug Conjugate/ADC Related

Bioactivity

Sulfo-DGN462 sodium undergoes degradation to DGN462 when subjected to culture medium and plasma. DGN462, a highly effective DNA-alkylating agent, exhibits anti-tumor properties that are particularly active against acute myeloid leukemia (AML) .

Smiles

[Na].[H][C@@]12Cc3ccccc3N1C(=O)c1cc(OC)c(OCc3cc(COc4cc5NC([C@]6([H])Cc7ccccc7N6C(=O)c5cc4OC)S(O)(=O)=O)cc(c3)N(CCOCCOCCOC)CC(C)(C)S)cc1NC2

Molecular Formula

C53H60N5NaO12S2

Molecular Weight

1046.19

Shipping Conditions

Cool pack

Storage Temperature

-20°C

Curated Selection

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