CR-1-31-B
Product Specifications
CAS Number
1352914-52-3
Target
Others, PERK, Apoptosis
Related Pathways
Apoptosis, Others
Bioactivity
CR-1-31-B, a synthetic rocaglate, acts as a highly potent inhibitor of eIF4A. By disrupting the interaction between eIF4A and RNA, it effectively obstructs the initiation phase of protein synthesis. Specifically, CR-1-31-B interferes with the association between Plasmodium falciparum eIF4A (PfeIF4A) and RNA. Additionally, CR-1-31-B induces apoptosis in neuroblastoma and gallbladder cancer cells [4].
Smiles
CONC(=O)[C@H]1[C@@H](O)[C@@]2(O)c3c(O[C@]2([C@@H]1c1ccccc1)c1ccc(OC)cc1)cc(OC)cc3OC
Molecular Formula
C28H29NO8
Molecular Weight
507.539
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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