EW-7195
Product Specifications
CAS Number
1352609-28-9
Target
P38 MAPK, ALK, TGF-beta/Smad
Related Pathways
MAPK, Tyrosine Kinase/Adaptors, Angiogenesis, Stem Cells
Purity
0.9998
Bioactivity
EW-7195 is a selective and potent inhibitor of ALK5 (TGFβR1) with an IC50 value of 4.83 nM.EW-7195 has an affinity for ALK5 that is more than 300-fold higher than that of p38α.EW-7195 has an inhibitory effect on TGF-β1-induced Smad signaling, epithelial mesenchymal transition (EMT), and breast cancer metastasis to the lungs.
Smiles
Cc1cccc(n1)-c1[nH]c(CNc2cccc(c2)C#N)nc1-c1ccc2ncnn2c1
Molecular Formula
C23H18N8
Molecular Weight
406.44
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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