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HG-7-85-01

Product Specifications

CAS Number

1258391-13-7

Target

JAK, Apoptosis, PDGFR, c-Kit, Src, Bcr-Abl

Related Pathways

JAK/STAT signaling, Stem Cells, Cytoskeletal Signaling, Apoptosis, Chromatin/Epigenetic, Tyrosine Kinase/Adaptors, Angiogenesis

Purity

0.9808

Bioactivity

HG-7-85-01 is a novel ATP-competitive and type II tyrosine kinase inhibitor targeting both wild-type and watchman mutant BCR-ABL, PDGFRα, Kit, and Src kinases, with inhibitory effects on the proliferation of a variety of cancer cell lines, leading to G0/G1-phase blockade and apoptosis induction in BCR-ABL-expressing cells.

Smiles

O=C(NC1=CC=C(C(=C1)C(F)(F)F)CN2CCN(CC)CC2)C3=CC=CC(=C3)C4=NC=5SC(=NC5C=C4)NC(=O)C6CC6

Molecular Formula

C31H31F3N6O2S

Molecular Weight

608.68

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

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