HG-7-85-01
Product Specifications
CAS Number
1258391-13-7
Target
JAK|||Apoptosis|||PDGFR|||c-Kit|||Src|||Bcr-Abl
Related Pathways
JAK/STAT signaling|||Stem Cells|||Cytoskeletal Signaling|||Apoptosis|||Chromatin/Epigenetic|||Tyrosine Kinase/Adaptors|||Angiogenesis
Purity
0.9808
Bioactivity
HG-7-85-01 is a novel ATP-competitive and type II tyrosine kinase inhibitor targeting both wild-type and watchman mutant BCR-ABL, PDGFR?, Kit, and Src kinases, with inhibitory effects on the proliferation of a variety of cancer cell lines, leading to G0/G1-phase blockade and apoptosis induction in BCR-ABL-expressing cells.
Smiles
O=C(NC1=CC=C(C(=C1)C(F)(F)F)CN2CCN(CC)CC2)C3=CC=CC(=C3)C4=NC=5SC(=NC5C=C4)NC(=O)C6CC6
Molecular Formula
C31H31F3N6O2S
Molecular Weight
608.68
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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