AP 811
Product Specifications
CAS Number
124833-45-0
Target
Natriuretic peptide
Related Pathways
GPCR/G Protein
Bioactivity
AP 811, a selective antagonist of the atrial natriuretic peptide clearance receptor (APN-CR, NPR3) with a K i value of 0.48 nM, exhibits remarkable selectivity for NPR3 over NPR1 by more than 20,000-fold. Moreover, AP 811 effectively eliminates ANP-induced pump stimulation.
Smiles
CCC(C)CNC(=O)C(CCCNC(N)=N)NC(=O)C(CC(O)=O)NC(=O)C(NC(=O)C(CCCNC(N)=N)NC(=O)Cc1ccc(NC(=O)c2ccc3ccccc3c2)cc1)C(C)CC
Molecular Formula
C46H66N12O8
Molecular Weight
915.11
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
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